Tafamidis Meglumine
Brand name: Vyndaqel
Rank #337 of 500 drugs by total cost
Data: CMS Medicare Part D, 2023 (most current available) · Updated March 2026
$31.0M
Total Cost
1,387
Total Claims
$31.0M
Total Cost
80
Prescribers
$22K
Cost per Claim
11
Beneficiaries
1,444
30-Day Fills
$387K
Avg Cost/Provider
17
Avg Claims/Provider
Share of Medicare Part D Spending
0.01%
of total Medicare Part D spending
$31.0M of $275.65B
Top Prescribers by Cost
Top 10 prescribers of $31.0M total
🔎 Data Overview
At $22,333 per prescription, this is a high-cost medication. Expensive drugs drive Medicare spending growth and create access challenges for patients with coverage gaps.
Average cost of $387,205 per prescriber suggests this drug may be concentrated among specialists. High per-provider spending can sometimes indicate inappropriate prescribing or overly aggressive use.
Average cost of $2,816,036 per patient per year. Medications at this price point significantly impact patient out-of-pocket costs and Medicare spending.
Insights generated from CMS data analysis. Statistical patterns are not accusations — always consider clinical context.
Top Prescribers of Tafamidis Meglumine
| # | Provider | Specialty | Location | Claims | Cost |
|---|---|---|---|---|---|
| 1 | Edward Miller | Cardiology | New Haven, CT | 108 | $2.4M |
| 2 | Ronald Witteles | Cardiology | Stanford, CA | 53 | $1.2M |
| 3 | Daniel Borgeson | Cardiology | Rochester, MN | 51 | $1.1M |
| 4 | Margaret Cuomo | Nurse Practitioner | New York, NY | 41 | $1.0M |
| 5 | Sarah Cuddy | Cardiology | Boston, MA | 29 | $771K |
| 6 | Peter Van Buren | Cardiology | South Burlington, VT | 29 | $764K |
| 7 | Heather Sanders | Nurse Practitioner | Milwaukee, WI | 30 | $676K |
| 8 | David Wolinsky | Cardiology | Weston, FL | 29 | $635K |
| 9 | Alyce Vendetti | Physician Assistant | Lebanon, NH | 29 | $630K |
| 10 | Ahmad Iqbal | Advanced Heart Failure and Transplant Cardiology | Shenandoah, TX | 15 | $583K |
| 11 | Mazen Hanna | Advanced Heart Failure and Transplant Cardiology | Cleveland, OH | 27 | $570K |
| 12 | Jason Gajarsa | Internal Medicine | Fountain Valley, CA | 25 | $567K |
| 13 | Kaylee Baker | Nurse Practitioner | Philadelphia, PA | 22 | $558K |
| 14 | Joyce Meng | Cardiology | Farmington, CT | 15 | $550K |
| 15 | Parag Kale | Cardiology | Dallas, TX | 23 | $532K |
Top prescribers ranked by total cost for this drug in 2023.
Related Drugs by Cost
| # | Drug | Total Cost | Claims |
|---|---|---|---|
| 334 | Zolpidem Tartrate (Zolpidem Tartrate) | $31.3M | 3,144,599 |
| 335 | Lorazepam (Lorazepam) | $31.3M | 3,237,827 |
| 336 | Diphth,pertuss(Acell),tet Vac (Boostrix Tdap) | $31.2M | 466,555 |
| 337 | Tafamidis Meglumine (Vyndaqel) | $31.0M | 1,387 |
| 338 | Midodrine Hcl (Midodrine Hcl) | $30.9M | 383,390 |
| 339 | Sarilumab (Kevzara) | $30.5M | 6,822 |
| 340 | Dabrafenib Mesylate (Tafinlar) | $30.4M | 2,377 |
Related Analysis
Data from CMS Medicare Part D Prescriber-Drug Public Use File, 2023. Methodology