Collagenase Clostridium Hist.

Brand name: Santyl

Rank #217 of 500 drugs by total cost

Data: CMS Medicare Part D, 2023 (most current available) · Updated March 2026

$63.3M

Total Cost

70,641

Total Claims

$63.3M

Total Cost

2,838

Prescribers

$896

Cost per Claim

24,329

Beneficiaries

75,657

30-Day Fills

$22K

Avg Cost/Provider

Avg Claims/Provider

Share of Medicare Part D Spending

0.02%

of total Medicare Part D spending

$63.3M of $275.65B

Top 10 prescribers of $63.3M total

#	Provider	Specialty	Location	Claims	Cost
1	Ernesto Arteaga	Nurse Practitioner	Miami, FL	200	$1.6M
2	Paul Ferraro	General Surgery	Cuyahoga Falls, OH	301	$1.4M
3	Josue Moran	Nurse Practitioner	Miami, FL	275	$1.2M
4	Carlos Arteta Higgins	Nurse Practitioner	Miami, FL	64	$610K
5	Timothy Estes	Family Practice	Jackson, MS	289	$537K
6	Riggi Wilsant	Nurse Practitioner	Brooklyn, NY	208	$536K
7	Kimberly Barrie	Orthopedic Surgery	Miramar, FL	75	$524K
8	Bruce Kava	Urology	Miami, FL	32	$422K
9	Wilson Knight	Family Practice	Tulsa, OK	18	$409K
10	Raj Shah	Family Practice	Miramar, FL	94	$402K
11	Anthony Kao	Nurse Practitioner	Los Angeles, CA	18	$385K
12	Yakoub Katri	Nephrology	Brooklyn, NY	215	$364K
13	Scott Gorenstein	General Surgery	Mineola, NY	72	$357K
14	Barbara Aguilar Espinoza	Family Practice	Miramar, FL	128	$335K
15	Nathan Bryant	Nurse Practitioner	Peoria, IL	26	$335K

Top prescribers ranked by total cost for this drug in 2023.

#	Drug	Total Cost	Claims
214	Venlafaxine Hcl (Venlafaxine Hcl)	$64.7M	2,187,710
215	Canagliflozin (Invokana)	$63.7M	66,550
216	Belimumab (Benlysta)	$63.4M	13,386
217	Collagenase Clostridium Hist. (Santyl)	$63.3M	70,641
218	Insulin Lispro Protamin/Lispro (Humalog Mix 75-25 Kwikpen)	$62.8M	60,873
219	Furosemide (Furosemide)	$62.3M	9,788,207
220	Buprenorphine (Buprenorphine)	$61.1M	156,598

The 20 drugs that cost Medicare the most.

Why some providers resist cheaper generics.

How pharmacy benefit managers drive up drug prices.

Data from CMS Medicare Part D Prescriber-Drug Public Use File, 2023. Methodology