Insulin Lispro Protamin/Lispro
Brand name: Humalog Mix 75-25 Kwikpen
Rank #218 of 500 drugs by total cost
Data: CMS Medicare Part D, 2023 (most current available) · Updated March 2026
$62.8M
Total Cost
60,873
Total Claims
$62.8M
Total Cost
2,872
Prescribers
$1,032
Cost per Claim
4,249
Beneficiaries
90,766
30-Day Fills
$22K
Avg Cost/Provider
21
Avg Claims/Provider
Share of Medicare Part D Spending
0.02%
of total Medicare Part D spending
$62.8M of $275.65B
Top Prescribers by Cost
Top 10 prescribers of $62.8M total
🔎 Data Overview
At $1,032 per prescription, this is a high-cost medication. Expensive drugs drive Medicare spending growth and create access challenges for patients with coverage gaps.
Average cost of $14,784 per patient per year. Medications at this price point significantly impact patient out-of-pocket costs and Medicare spending.
Insights generated from CMS data analysis. Statistical patterns are not accusations — always consider clinical context.
Top Prescribers of Insulin Lispro Protamin/Lispro
| # | Provider | Specialty | Location | Claims | Cost |
|---|---|---|---|---|---|
| 1 | Willie Teo Ong | Endocrinology | Brownsville, TX | 266 | $825K |
| 2 | Enrique Griego | Family Practice | Mcallen, TX | 326 | $527K |
| 3 | Katherine Montoto | Nurse Practitioner | Jefferson City, TN | 241 | $500K |
| 4 | Helen Slone | Endocrinology | Vineland, NJ | 220 | $332K |
| 5 | Roberto Ortiz | Internal Medicine | Providence, RI | 184 | $331K |
| 6 | Michael Lin | Endocrinology | San Gabriel, CA | 253 | $305K |
| 7 | Mubashir Mahmood | Endocrinology | Knoxville, TN | 160 | $305K |
| 8 | Nicholas Shelley | Nurse Practitioner | Fort Myers, FL | 114 | $292K |
| 9 | Mohamed Zeitoun | Endocrinology | Hobart, IN | 141 | $285K |
| 10 | Kandaswamy Jayaraj | Endocrinology | Beaumont, TX | 156 | $280K |
| 11 | Carlos Rivera | Endocrinology | Miami, FL | 299 | $252K |
| 12 | Michael Mellman | Endocrinology | Boynton Beach, FL | 147 | $216K |
| 13 | Athanassios Drimoussis | Endocrinology | Fort Myers, FL | 103 | $215K |
| 14 | Denise Caro | Endocrinology | Mayaguez, PR | 244 | $212K |
| 15 | David Escalante | Internal Medicine | Jellico, TN | 114 | $201K |
Top prescribers ranked by total cost for this drug in 2023.
Related Drugs by Cost
| # | Drug | Total Cost | Claims |
|---|---|---|---|
| 215 | Canagliflozin (Invokana) | $63.7M | 66,550 |
| 216 | Belimumab (Benlysta) | $63.4M | 13,386 |
| 217 | Collagenase Clostridium Hist. (Santyl) | $63.3M | 70,641 |
| 218 | Insulin Lispro Protamin/Lispro (Humalog Mix 75-25 Kwikpen) | $62.8M | 60,873 |
| 219 | Furosemide (Furosemide) | $62.3M | 9,788,207 |
| 220 | Buprenorphine (Buprenorphine) | $61.1M | 156,598 |
| 221 | Ferric Citrate (Auryxia) | $60.7M | 32,798 |
Related Analysis
Data from CMS Medicare Part D Prescriber-Drug Public Use File, 2023. Methodology