Alpha-1-Proteinase Inhibitor
Brand name: Prolastin C
Rank #122 of 500 drugs by total cost
Data: CMS Medicare Part D, 2023 (most current available) · Updated March 2026
$137.9M
Total Cost
12,352
Total Claims
$137.9M
Total Cost
713
Prescribers
$11K
Cost per Claim
39
Beneficiaries
12,364
30-Day Fills
$193K
Avg Cost/Provider
17
Avg Claims/Provider
Share of Medicare Part D Spending
0.05%
of total Medicare Part D spending
$137.9M of $275.65B
Top Prescribers by Cost
Top 10 prescribers of $137.9M total
🔎 Data Overview
At $11,167 per prescription, this is a high-cost medication. Expensive drugs drive Medicare spending growth and create access challenges for patients with coverage gaps.
Average cost of $193,449 per prescriber suggests this drug may be concentrated among specialists. High per-provider spending can sometimes indicate inappropriate prescribing or overly aggressive use.
Average cost of $3,536,650 per patient per year. Medications at this price point significantly impact patient out-of-pocket costs and Medicare spending.
Insights generated from CMS data analysis. Statistical patterns are not accusations — always consider clinical context.
Top Prescribers of Alpha-1-Proteinase Inhibitor
| # | Provider | Specialty | Location | Claims | Cost |
|---|---|---|---|---|---|
| 1 | Mahmood Alam | Pulmonary Disease | Whitesburg, KY | 162 | $2.1M |
| 2 | Christina Eagan | Nurse Practitioner | Gainesville, FL | 136 | $1.8M |
| 3 | Mahmood Alam | Pulmonary Disease | Whitesburg, KY | 99 | $1.5M |
| 4 | Karina Serban | Pulmonary Disease | Gainesville, FL | 93 | $1.2M |
| 5 | Elias Issa | Emergency Medicine | Blue Ridge, GA | 79 | $938K |
| 6 | Humam Farah | Pulmonary Disease | Hannibal, MO | 62 | $902K |
| 7 | Joshua Aaron | Pulmonary Disease | Elkton, MD | 72 | $847K |
| 8 | Elie Saab | Pulmonary Disease | Portsmouth, OH | 48 | $750K |
| 9 | Christy Martin | Nurse Practitioner | Portsmouth, OH | 46 | $678K |
| 10 | Ramesh Kaul | Pulmonary Disease | New Castle, PA | 38 | $674K |
| 11 | David Mares | Pulmonary Disease | Anderson, IN | 53 | $639K |
| 12 | Bruce Trapnell | Pulmonary Disease | Cincinnati, OH | 60 | $607K |
| 13 | Charlton Strange | Pulmonary Disease | Charleston, SC | 40 | $576K |
| 14 | David Nyanjom | Pulmonary Disease | Columbia, MD | 51 | $563K |
| 15 | Abul Azad | Pulmonary Disease | Schenectady, NY | 59 | $558K |
Top prescribers ranked by total cost for this drug in 2023.
Related Drugs by Cost
| # | Drug | Total Cost | Claims |
|---|---|---|---|
| 119 | Ofatumumab (Kesimpta Pen) | $144.6M | 14,774 |
| 120 | Emtricitab/Rilpiviri/Tenof Ala (Odefsey) | $144.1M | 37,441 |
| 121 | Eltrombopag Olamine (Promacta) | $142.8M | 10,876 |
| 122 | Alpha-1-Proteinase Inhibitor (Prolastin C) | $137.9M | 12,352 |
| 123 | Dasatinib (Sprycel) | $136.8M | 10,389 |
| 124 | Oxycodone Hcl/Acetaminophen (Oxycodone-Acetaminophen) | $136.4M | 3,487,099 |
| 125 | Buprenorphine Hcl/Naloxone Hcl (Buprenorphine-Naloxone) | $135.8M | 696,008 |
Related Analysis
Data from CMS Medicare Part D Prescriber-Drug Public Use File, 2023. Methodology