Upadacitinib
Brand name: Rinvoq
Rank #52 of 500 drugs by total cost
Data: CMS Medicare Part D, 2023 (most current available) · Updated March 2026
$346.0M
Total Cost
51,469
Total Claims
$346.0M
Total Cost
1,595
Prescribers
$6,723
Cost per Claim
2,810
Beneficiaries
53,390
30-Day Fills
$217K
Avg Cost/Provider
32
Avg Claims/Provider
Share of Medicare Part D Spending
0.13%
of total Medicare Part D spending
$346.0M of $275.65B
Top Prescribers by Cost
Top 10 prescribers of $346.0M total
🔎 Data Overview
At $6,723 per prescription, this is a high-cost medication. Expensive drugs drive Medicare spending growth and create access challenges for patients with coverage gaps.
Average cost of $216,949 per prescriber suggests this drug may be concentrated among specialists. High per-provider spending can sometimes indicate inappropriate prescribing or overly aggressive use.
Average cost of $123,144 per patient per year. Medications at this price point significantly impact patient out-of-pocket costs and Medicare spending.
Insights generated from CMS data analysis. Statistical patterns are not accusations — always consider clinical context.
Top Prescribers of Upadacitinib
| # | Provider | Specialty | Location | Claims | Cost |
|---|---|---|---|---|---|
| 1 | Mansoor Ahmed | Rheumatology | Richmond, KY | 330 | $2.2M |
| 2 | Brian Huh | Rheumatology | Los Angeles, CA | 320 | $2.1M |
| 3 | Luis Salayandia | Rheumatology | El Paso, TX | 316 | $2.0M |
| 4 | Saravanan Thiagarajan | Rheumatology | Baton Rouge, LA | 277 | $1.8M |
| 5 | Frederick Murphy | Rheumatology | Duncansville, PA | 258 | $1.7M |
| 6 | Robert Holmes | Rheumatology | Pollocksville, NC | 250 | $1.7M |
| 7 | Fatima Khan | Rheumatology | Floral Park, NY | 242 | $1.6M |
| 8 | Ronald George | Rheumatology | Wilmington, NC | 215 | $1.5M |
| 9 | Edmund Lacour | Rheumatology | Dothan, AL | 214 | $1.4M |
| 10 | Angela Pham | Rheumatology | Carrollton, GA | 191 | $1.3M |
| 11 | Safwan Sakr | Internal Medicine | Little Rock, AR | 179 | $1.3M |
| 12 | Fahed Hamadeh | Rheumatology | Oklahoma City, OK | 190 | $1.2M |
| 13 | Salman Ahmad | Family Practice | Lubbock, TX | 181 | $1.2M |
| 14 | James Gore | Rheumatology | Nashville, TN | 182 | $1.2M |
| 15 | Amarilis Torres | Rheumatology | Zephyrhills, FL | 177 | $1.2M |
Top prescribers ranked by total cost for this drug in 2023.
Related Drugs by Cost
| # | Drug | Total Cost | Claims |
|---|---|---|---|
| 49 | Aripiprazole (Aripiprazole) | $373.1M | 1,494,971 |
| 50 | Apalutamide (Erleada) | $369.2M | 24,956 |
| 51 | Secukinumab (Cosentyx Sensoready (2 Pens)) | $347.7M | 45,496 |
| 52 | Upadacitinib (Rinvoq) | $346.0M | 51,469 |
| 53 | Abiraterone Acetate (Abiraterone Acetate) | $345.0M | 122,643 |
| 54 | Icosapent Ethyl (Vascepa) | $334.9M | 692,252 |
| 55 | Cariprazine Hcl (Vraylar) | $329.1M | 226,854 |
Related Analysis
Data from CMS Medicare Part D Prescriber-Drug Public Use File, 2023. Methodology