Trametinib Dimethyl Sulfoxide
Brand name: Mekinist
Rank #317 of 500 drugs by total cost
Data: CMS Medicare Part D, 2023 (most current available) · Updated March 2026
$35.0M
Total Cost
2,448
Total Claims
$35.0M
Total Cost
161
Prescribers
$14K
Cost per Claim
11
Beneficiaries
2,454
30-Day Fills
$217K
Avg Cost/Provider
15
Avg Claims/Provider
Share of Medicare Part D Spending
0.01%
of total Medicare Part D spending
$35.0M of $275.65B
Top Prescribers by Cost
Top 10 prescribers of $35.0M total
🔎 Data Overview
At $14,284 per prescription, this is a high-cost medication. Expensive drugs drive Medicare spending growth and create access challenges for patients with coverage gaps.
Average cost of $217,192 per prescriber suggests this drug may be concentrated among specialists. High per-provider spending can sometimes indicate inappropriate prescribing or overly aggressive use.
Average cost of $3,178,908 per patient per year. Medications at this price point significantly impact patient out-of-pocket costs and Medicare spending.
Insights generated from CMS data analysis. Statistical patterns are not accusations — always consider clinical context.
Top Prescribers of Trametinib Dimethyl Sulfoxide
| # | Provider | Specialty | Location | Claims | Cost |
|---|---|---|---|---|---|
| 1 | Kenneth Ain | Endocrinology | Lexington, KY | 58 | $773K |
| 2 | Jiaxin Niu | Hematology-Oncology | Gilbert, AZ | 40 | $634K |
| 3 | Victoria Villaflor | Medical Oncology | Duarte, CA | 38 | $616K |
| 4 | Mabel Ryder | Endocrinology | Rochester, MN | 52 | $580K |
| 5 | Priyanka Iyer | Endocrinology | Houston, TX | 28 | $447K |
| 6 | Jesse Keller | Internal Medicine | Saint Louis, MO | 27 | $446K |
| 7 | Peter Everett | Internal Medicine | Boston, MA | 26 | $415K |
| 8 | Mario Sznol | Medical Oncology | New Haven, CT | 24 | $388K |
| 9 | Sasan Fazeli | Endocrinology | Duarte, CA | 23 | $365K |
| 10 | Lavanya Tiriveedhi | Hematology-Oncology | Springfield, MO | 23 | $362K |
| 11 | Conor Steuer | Hematology-Oncology | Atlanta, GA | 23 | $359K |
| 12 | Ammar Sukari | Medical Oncology | Detroit, MI | 30 | $353K |
| 13 | Surabhi Pathak | Hematology-Oncology | Ashland, KY | 21 | $351K |
| 14 | Eric Santos | Hematology-Oncology | Grand Rapids, MI | 23 | $351K |
| 15 | Ted Huang | Hematology-Oncology | Gresham, OR | 22 | $349K |
Top prescribers ranked by total cost for this drug in 2023.
Related Drugs by Cost
| # | Drug | Total Cost | Claims |
|---|---|---|---|
| 314 | Lisdexamfetamine Dimesylate (Lisdexamfetamine Dimesylate) | $35.7M | 88,692 |
| 315 | Ketoconazole (Ketoconazole) | $35.4M | 1,346,512 |
| 316 | Oxcarbazepine (Oxcarbazepine) | $35.3M | 430,248 |
| 317 | Trametinib Dimethyl Sulfoxide (Mekinist) | $35.0M | 2,448 |
| 318 | Isosorbide Mononitrate (Isosorbide Mononitrate Er) | $34.5M | 1,805,114 |
| 319 | Clonazepam (Clonazepam) | $34.4M | 3,685,968 |
| 320 | Tolvaptan (Jynarque) | $34.4M | 2,760 |
Related Analysis
Data from CMS Medicare Part D Prescriber-Drug Public Use File, 2023. Methodology