Tafamidis
Brand name: Vyndamax
Rank #37 of 500 drugs by total cost
Data: CMS Medicare Part D, 2023 (most current available) · Updated March 2026
$511.1M
Total Cost
20,589
Total Claims
$511.1M
Total Cost
507
Prescribers
$25K
Cost per Claim
1,522
Beneficiaries
23,154
30-Day Fills
$1.0M
Avg Cost/Provider
41
Avg Claims/Provider
Share of Medicare Part D Spending
0.19%
of total Medicare Part D spending
$511.1M of $275.65B
Top Prescribers by Cost
Top 10 prescribers of $511.1M total
🔎 Data Overview
Ranked #37 out of 500 drugs tracked by total cost. Tafamidis represents a significant portion of Medicare drug spending.
At $24,823 per prescription, this is a high-cost medication. Expensive drugs drive Medicare spending growth and create access challenges for patients with coverage gaps.
Average cost of $1,008,060 per prescriber suggests this drug may be concentrated among specialists. High per-provider spending can sometimes indicate inappropriate prescribing or overly aggressive use.
Average cost of $335,799 per patient per year. Medications at this price point significantly impact patient out-of-pocket costs and Medicare spending.
Insights generated from CMS data analysis. Statistical patterns are not accusations — always consider clinical context.
Top Prescribers of Tafamidis
| # | Provider | Specialty | Location | Claims | Cost |
|---|---|---|---|---|---|
| 1 | Sarah Cuddy | Cardiology | Boston, MA | 800 | $19.9M |
| 2 | Zubair Shah | Advanced Heart Failure and Transplant Cardiology | Kansas City, KS | 686 | $15.2M |
| 3 | Margaret Cuomo | Nurse Practitioner | New York, NY | 464 | $13.1M |
| 4 | Sabeena Arora | Cardiology | Hartford, CT | 346 | $12.2M |
| 5 | Ronald Witteles | Cardiology | Stanford, CA | 500 | $11.0M |
| 6 | Janice Pieretti | Advanced Heart Failure and Transplant Cardiology | Philadelphia, PA | 407 | $9.8M |
| 7 | Kaylee Baker | Nurse Practitioner | Philadelphia, PA | 357 | $8.9M |
| 8 | Edward Miller | Cardiology | New Haven, CT | 304 | $8.6M |
| 9 | Yevgeniy Brailovsky | Cardiology | New York, NY | 382 | $8.4M |
| 10 | Ahmad Masri | Cardiology | Portland, OR | 275 | $7.9M |
| 11 | Prem Soman | Cardiology | Pittsburgh, PA | 296 | $7.1M |
| 12 | Rebecca Hung | Cardiology | Nashville, TN | 263 | $6.5M |
| 13 | David Wolinsky | Cardiology | Weston, FL | 282 | $6.4M |
| 14 | Julie Rosenthal | Advanced Heart Failure and Transplant Cardiology | Phoenix, AZ | 265 | $6.2M |
| 15 | Frederick Ruberg | Cardiology | Boston, MA | 253 | $6.0M |
Top prescribers ranked by total cost for this drug in 2023.
Related Drugs by Cost
| # | Drug | Total Cost | Claims |
|---|---|---|---|
| 34 | Valbenazine Tosylate (Ingrezza) | $553.8M | 73,914 |
| 35 | Fluticasone Propion/Salmeterol (Advair Diskus) | $523.2M | 1,289,942 |
| 36 | Varicella-Zoster Ge/As01b/Pf (Shingrix) | $514.4M | 2,419,884 |
| 37 | Tafamidis (Vyndamax) | $511.1M | 20,589 |
| 38 | Fluticasone/Vilanterol (Breo Ellipta) | $493.0M | 909,837 |
| 39 | Tiotropium Bromide (Spiriva Handihaler) | $478.1M | 673,800 |
| 40 | Evolocumab (Repatha Sureclick) | $460.5M | 528,560 |
Related Analysis
Data from CMS Medicare Part D Prescriber-Drug Public Use File, 2023. Methodology