Sofosbuvir/Velpatasvir
Brand name: Epclusa
Rank #116 of 500 drugs by total cost
Data: CMS Medicare Part D, 2023 (most current available) · Updated March 2026
$149.4M
Total Cost
6,544
Total Claims
$149.4M
Total Cost
289
Prescribers
$23K
Cost per Claim
1,121
Beneficiaries
6,562
30-Day Fills
$517K
Avg Cost/Provider
23
Avg Claims/Provider
Share of Medicare Part D Spending
0.05%
of total Medicare Part D spending
$149.4M of $275.65B
Top Prescribers by Cost
Top 10 prescribers of $149.4M total
🔎 Data Overview
At $22,831 per prescription, this is a high-cost medication. Expensive drugs drive Medicare spending growth and create access challenges for patients with coverage gaps.
Average cost of $516,973 per prescriber suggests this drug may be concentrated among specialists. High per-provider spending can sometimes indicate inappropriate prescribing or overly aggressive use.
Average cost of $133,279 per patient per year. Medications at this price point significantly impact patient out-of-pocket costs and Medicare spending.
Insights generated from CMS data analysis. Statistical patterns are not accusations — always consider clinical context.
Top Prescribers of Sofosbuvir/Velpatasvir
| # | Provider | Specialty | Location | Claims | Cost |
|---|---|---|---|---|---|
| 1 | Kim Hinojosa | Nurse Practitioner | San Antonio, TX | 430 | $11.5M |
| 2 | Babiswarup Chandamuri | Gastroenterology | Houma, LA | 296 | $7.9M |
| 3 | Kenzie Reeder | Nurse Practitioner | Louisville, KY | 135 | $3.6M |
| 4 | Richard Manch | Gastroenterology | Glendale, AZ | 97 | $2.6M |
| 5 | Jihad Slim | Infectious Disease | Newark, NJ | 94 | $2.5M |
| 6 | Andrea Stewart | Nurse Practitioner | Pittsburgh, PA | 73 | $1.9M |
| 7 | Colleen Green | Physician Assistant | Charlottesville, VA | 72 | $1.8M |
| 8 | Amber Grinnell | Nurse Practitioner | Pittsburgh, PA | 57 | $1.5M |
| 9 | Elaine Engelsman | Nurse Practitioner | Muskegon, MI | 53 | $1.4M |
| 10 | Jeffrey Mcmahon | Physician Assistant | Grosse Pointe Woods, MI | 51 | $1.3M |
| 11 | Tracy Gowan | Nurse Practitioner | Louisville, KY | 45 | $1.2M |
| 12 | Manish Thapar | Gastroenterology | Philadelphia, PA | 46 | $1.2M |
| 13 | Annie Giller | Nurse Practitioner | Cleveland, OH | 47 | $1.2M |
| 14 | Lucy Ledesma | Nurse Practitioner | Grand Rapids, MI | 46 | $1.2M |
| 15 | Lav Singh | Internal Medicine | Paris, TX | 43 | $1.1M |
Top prescribers ranked by total cost for this drug in 2023.
Related Drugs by Cost
| # | Drug | Total Cost | Claims |
|---|---|---|---|
| 113 | Rimegepant Sulfate (Nurtec Odt) | $155.0M | 106,692 |
| 114 | Teriparatide (Forteo) | $153.9M | 38,259 |
| 115 | Ixekizumab (Taltz Autoinjector) | $149.8M | 19,972 |
| 116 | Sofosbuvir/Velpatasvir (Epclusa) | $149.4M | 6,544 |
| 117 | Dolutegravir/Rilpivirine (Juluca) | $148.9M | 41,081 |
| 118 | Lisinopril (Lisinopril) | $145.8M | 15,744,768 |
| 119 | Ofatumumab (Kesimpta Pen) | $144.6M | 14,774 |
Related Analysis
Data from CMS Medicare Part D Prescriber-Drug Public Use File, 2023. Methodology