Sodium Oxybate
Brand name: Xyrem
Rank #313 of 500 drugs by total cost
Data: CMS Medicare Part D, 2023 (most current available) · Updated March 2026
$35.8M
Total Cost
2,160
Total Claims
$35.8M
Total Cost
149
Prescribers
$17K
Cost per Claim
0
Beneficiaries
2,160
30-Day Fills
$240K
Avg Cost/Provider
14
Avg Claims/Provider
Share of Medicare Part D Spending
0.01%
of total Medicare Part D spending
$35.8M of $275.65B
Top Prescribers by Cost
Top 10 prescribers of $35.8M total
🔎 Data Overview
At $16,566 per prescription, this is a high-cost medication. Expensive drugs drive Medicare spending growth and create access challenges for patients with coverage gaps.
Average cost of $240,155 per prescriber suggests this drug may be concentrated among specialists. High per-provider spending can sometimes indicate inappropriate prescribing or overly aggressive use.
Insights generated from CMS data analysis. Statistical patterns are not accusations — always consider clinical context.
Top Prescribers of Sodium Oxybate
| # | Provider | Specialty | Location | Claims | Cost |
|---|---|---|---|---|---|
| 1 | Adrian Santamaria | Neurology | Tomball, TX | 40 | $675K |
| 2 | Humberto Battistini | Neurology | Milwaukee, WI | 37 | $571K |
| 3 | Michael Thorpy | Neurology | Bronx, NY | 33 | $564K |
| 4 | William Prey | Psychiatry & Neurology | San Francisco, CA | 17 | $496K |
| 5 | Oscar Schwartz | Sleep Medicine | Saint Louis, MO | 24 | $481K |
| 6 | Richard Cho | Neurology | Reston, VA | 29 | $470K |
| 7 | Thomas Scammell | Neurology | Boston, MA | 29 | $461K |
| 8 | Ross Bacon | Pulmonary Disease | Sioux Falls, SD | 21 | $432K |
| 9 | Kuimil Mohan | Neurology | Indianapolis, IN | 21 | $418K |
| 10 | Donald Howard | Sleep Medicine | Spokane, WA | 22 | $404K |
| 11 | Karin Johnson | Neurology | Springfield, MA | 26 | $395K |
| 12 | Mari Goldner | Pulmonary Disease | Corvallis, OR | 19 | $382K |
| 13 | Humberto Battistini | Neurology | Milwaukee, WI | 21 | $380K |
| 14 | Jane Ayala | Rheumatology | San Antonio, TX | 18 | $363K |
| 15 | Kimberly Mebust | Neurology | Tacoma, WA | 24 | $340K |
Top prescribers ranked by total cost for this drug in 2023.
Related Drugs by Cost
| # | Drug | Total Cost | Claims |
|---|---|---|---|
| 310 | Alprazolam (Alprazolam) | $36.1M | 4,899,372 |
| 311 | Naloxegol Oxalate (Movantik) | $36.1M | 85,094 |
| 312 | Valacyclovir Hcl (Valacyclovir) | $35.9M | 827,731 |
| 313 | Sodium Oxybate (Xyrem) | $35.8M | 2,160 |
| 314 | Lisdexamfetamine Dimesylate (Lisdexamfetamine Dimesylate) | $35.7M | 88,692 |
| 315 | Ketoconazole (Ketoconazole) | $35.4M | 1,346,512 |
| 316 | Oxcarbazepine (Oxcarbazepine) | $35.3M | 430,248 |
Related Analysis
Data from CMS Medicare Part D Prescriber-Drug Public Use File, 2023. Methodology