Alprazolam
Rank #310 of 500 drugs by total cost
Data: CMS Medicare Part D, 2023 (most current available) · Updated March 2026
$36.1M
Total Cost
4,899,372
Total Claims
$36.1M
Total Cost
73,891
Prescribers
$7
Cost per Claim
924,111
Beneficiaries
5,294,722
30-Day Fills
$489
Avg Cost/Provider
66
Avg Claims/Provider
Share of Medicare Part D Spending
0.01%
of total Medicare Part D spending
$36.1M of $275.65B
Top Prescribers by Cost
Top 10 prescribers of $36.1M total
🔎 Data Overview
At $7.00 per prescription, this is an affordable generic medication. Wider use of affordable generics like this could save Medicare billions annually.
Benzodiazepines carry an FDA Black Box Warning when co-prescribed with opioids due to increased overdose risk. We track providers prescribing both drug classes to identify potentially dangerous combinations.
Insights generated from CMS data analysis. Statistical patterns are not accusations — always consider clinical context.
Top Prescribers of Alprazolam
| # | Provider | Specialty | Location | Claims | Cost |
|---|---|---|---|---|---|
| 1 | Isaac Snapp | Physician Assistant | Darlington, SC | 88 | $50K |
| 2 | Timothy Cullinane | Psychiatry | Elmhurst, IL | 36 | $49K |
| 3 | Vicotr Mariano Mercedes | Family Practice | Vega Baja, PR | 4,696 | $39K |
| 4 | Isabel Mendoza | Family Practice | Darlington, SC | 69 | $38K |
| 5 | Jorge Quintana | Psychiatry | Rahway, NJ | 48 | $32K |
| 6 | Patrick Nettles | Physician Assistant | Manning, SC | 41 | $31K |
| 7 | David Boyer | Psychiatry & Neurology | Scottsdale, AZ | 40 | $27K |
| 8 | Richard Vannieuwenhuize | Internal Medicine | Lincoln, RI | 14 | $26K |
| 9 | James Aills | Psychiatry | Flint, MI | 14 | $26K |
| 10 | Maritza Ortiz Acosta | Psychiatry | Ponce, PR | 3,520 | $26K |
| 11 | Marcia Zuckerman | Psychiatry | Brookline, MA | 13 | $26K |
| 12 | Hugh Hall | Internal Medicine | Augusta, GA | 13 | $24K |
| 13 | Eugene Gibilaro | Internal Medicine | Brooklyn, NY | 13 | $24K |
| 14 | Jorge De Jesus | Psychiatry & Neurology | Mayaguez, PR | 3,658 | $24K |
| 15 | John Paulsel | Internal Medicine | Houston, TX | 23 | $21K |
Top prescribers ranked by total cost for this drug in 2023.
Related Drugs by Cost
| # | Drug | Total Cost | Claims |
|---|---|---|---|
| 307 | Azelastine Hcl (Azelastine Hcl) | $36.6M | 996,341 |
| 308 | Tizanidine Hcl (Tizanidine Hcl) | $36.5M | 2,602,362 |
| 309 | Fentanyl (Fentanyl) | $36.2M | 324,419 |
| 310 | Alprazolam (Alprazolam) | $36.1M | 4,899,372 |
| 311 | Naloxegol Oxalate (Movantik) | $36.1M | 85,094 |
| 312 | Valacyclovir Hcl (Valacyclovir) | $35.9M | 827,731 |
| 313 | Sodium Oxybate (Xyrem) | $35.8M | 2,160 |
Related Analysis
Data from CMS Medicare Part D Prescriber-Drug Public Use File, 2023. Methodology