Rifaximin
Brand name: Xifaxan
Rank #57 of 500 drugs by total cost
Data: CMS Medicare Part D, 2023 (most current available) · Updated March 2026
$310.0M
Total Cost
111,328
Total Claims
$310.0M
Total Cost
4,328
Prescribers
$2,785
Cost per Claim
9,522
Beneficiaries
114,153
30-Day Fills
$72K
Avg Cost/Provider
26
Avg Claims/Provider
Share of Medicare Part D Spending
0.11%
of total Medicare Part D spending
$310.0M of $275.65B
Top Prescribers by Cost
Top 10 prescribers of $310.0M total
🔎 Data Overview
At $2,785 per prescription, this is a high-cost medication. Expensive drugs drive Medicare spending growth and create access challenges for patients with coverage gaps.
Average cost of $32,556 per patient per year. Medications at this price point significantly impact patient out-of-pocket costs and Medicare spending.
Insights generated from CMS data analysis. Statistical patterns are not accusations — always consider clinical context.
Top Prescribers of Rifaximin
| # | Provider | Specialty | Location | Claims | Cost |
|---|---|---|---|---|---|
| 1 | Kim Hinojosa | Nurse Practitioner | San Antonio, TX | 663 | $2.2M |
| 2 | Macy Godman | Physician Assistant | Lexington, KY | 345 | $1.2M |
| 3 | Kimberly Akinyele | Nurse Practitioner | Nashville, TN | 350 | $1.2M |
| 4 | Rashid Syed | Gastroenterology | Tampa, FL | 352 | $1.2M |
| 5 | Hesham Elgouhari | Infectious Disease | Denison, TX | 333 | $1.1M |
| 6 | Sherry Wright | Nurse Practitioner | Cane Ridge, TN | 291 | $969K |
| 7 | Saurabh Agrawal | Gastroenterology | Indianapolis, IN | 266 | $887K |
| 8 | Conrad Ross | Physician Assistant | Duluth, MN | 207 | $755K |
| 9 | Phillip Henderson | Gastroenterology | Mobile, AL | 217 | $753K |
| 10 | Cassandre Oscar | Nurse Practitioner | Las Vegas, NV | 211 | $724K |
| 11 | Heather Simpson | Gastroenterology | Charleston, SC | 194 | $716K |
| 12 | Ira Willner | Gastroenterology | Charleston, SC | 202 | $712K |
| 13 | Brendan Mcguire | Gastroenterology | Birmingham, AL | 208 | $710K |
| 14 | Ryan Taylor | Gastroenterology | Kansas City, KS | 210 | $693K |
| 15 | Mohamad Rasm Alsibae | Gastroenterology | Royal Oak, MI | 198 | $685K |
Top prescribers ranked by total cost for this drug in 2023.
Related Drugs by Cost
| # | Drug | Total Cost | Claims |
|---|---|---|---|
| 54 | Icosapent Ethyl (Vascepa) | $334.9M | 692,252 |
| 55 | Cariprazine Hcl (Vraylar) | $329.1M | 226,854 |
| 56 | Albuterol Sulfate (Albuterol Sulfate Hfa) | $312.2M | 7,904,120 |
| 57 | Rifaximin (Xifaxan) | $310.0M | 111,328 |
| 58 | Sitagliptin Phos/Metformin Hcl (Janumet) | $302.2M | 329,315 |
| 59 | Tofacitinib Citrate (Xeljanz Xr) | $294.4M | 49,478 |
| 60 | Umeclidinium Brm/Vilanterol Tr (Anoro Ellipta) | $294.3M | 480,651 |
Related Analysis
Data from CMS Medicare Part D Prescriber-Drug Public Use File, 2023. Methodology