Pegloticase
Brand name: Krystexxa
Rank #245 of 500 drugs by total cost
Data: CMS Medicare Part D, 2023 (most current available) · Updated March 2026
$52.2M
Total Cost
1,134
Total Claims
$52.2M
Total Cost
59
Prescribers
$46K
Cost per Claim
26
Beneficiaries
1,134
30-Day Fills
$885K
Avg Cost/Provider
19
Avg Claims/Provider
Share of Medicare Part D Spending
0.02%
of total Medicare Part D spending
$52.2M of $275.65B
Top Prescribers by Cost
Top 10 prescribers of $52.2M total
🔎 Data Overview
At $46,038 per prescription, this is a high-cost medication. Expensive drugs drive Medicare spending growth and create access challenges for patients with coverage gaps.
Average cost of $884,869 per prescriber suggests this drug may be concentrated among specialists. High per-provider spending can sometimes indicate inappropriate prescribing or overly aggressive use.
Average cost of $2,007,971 per patient per year. Medications at this price point significantly impact patient out-of-pocket costs and Medicare spending.
Insights generated from CMS data analysis. Statistical patterns are not accusations — always consider clinical context.
Top Prescribers of Pegloticase
| # | Provider | Specialty | Location | Claims | Cost |
|---|---|---|---|---|---|
| 1 | Sunil Patel | Nephrology | Apple Valley, CA | 64 | $3.6M |
| 2 | Payam Shakouri | Nephrology | Poughkeepsie, NY | 55 | $3.1M |
| 3 | James Hunt | Internal Medicine | Tarpon Springs, FL | 69 | $2.5M |
| 4 | Gerald Ho | Rheumatology | La Palma, CA | 42 | $2.4M |
| 5 | Sandra Reed | Nurse Practitioner | Taylorsville, NC | 41 | $2.3M |
| 6 | Po Lew | Family Practice | Rosemead, CA | 34 | $1.9M |
| 7 | Samer Diab Agha | Nephrology | Fort Lauderdale, FL | 31 | $1.8M |
| 8 | Nizar Eskandar | Nephrology | Hinesville, GA | 24 | $1.4M |
| 9 | John Kang | Nephrology | Bronx, NY | 22 | $1.2M |
| 10 | Asim Singh | Nephrology | Erie, PA | 22 | $1.2M |
| 11 | Ramachandra Malya | Nephrology | Houston, TX | 20 | $1.2M |
| 12 | Joven Dungo | Internal Medicine | Jersey City, NJ | 22 | $1.1M |
| 13 | Alex Kawana | Medical Oncology | West Hollywood, CA | 25 | $1.0M |
| 14 | Stephen Kinard | Podiatry | Tarboro, NC | 18 | $1.0M |
| 15 | Sabeen Najam | Rheumatology | Baytown, TX | 17 | $949K |
Top prescribers ranked by total cost for this drug in 2023.
Related Drugs by Cost
| # | Drug | Total Cost | Claims |
|---|---|---|---|
| 242 | Oxybutynin Chloride (Oxybutynin Chloride Er) | $53.4M | 1,872,901 |
| 243 | Raltegravir Potassium (Isentress) | $53.0M | 25,491 |
| 244 | Belumosudil Mesylate (Rezurock) | $52.3M | 2,280 |
| 245 | Pegloticase (Krystexxa) | $52.2M | 1,134 |
| 246 | Estrogens, Conjugated (Premarin) | $52.0M | 130,171 |
| 247 | Ranolazine (Ranolazine Er) | $51.6M | 381,631 |
| 248 | Epoetin Alfa (Epogen) | $51.4M | 34,952 |
Related Analysis
Data from CMS Medicare Part D Prescriber-Drug Public Use File, 2023. Methodology