Istradefylline
Brand name: Nourianz
Rank #442 of 500 drugs by total cost
Data: CMS Medicare Part D, 2023 (most current available) · Updated March 2026
$17.8M
Total Cost
7,061
Total Claims
$17.8M
Total Cost
248
Prescribers
$2,523
Cost per Claim
526
Beneficiaries
9,573
30-Day Fills
$72K
Avg Cost/Provider
28
Avg Claims/Provider
Share of Medicare Part D Spending
0.01%
of total Medicare Part D spending
$17.8M of $275.65B
Top Prescribers by Cost
Top 10 prescribers of $17.8M total
🔎 Data Overview
At $2,523 per prescription, this is a high-cost medication. Expensive drugs drive Medicare spending growth and create access challenges for patients with coverage gaps.
Average cost of $33,870 per patient per year. Medications at this price point significantly impact patient out-of-pocket costs and Medicare spending.
Insights generated from CMS data analysis. Statistical patterns are not accusations — always consider clinical context.
Top Prescribers of Istradefylline
| # | Provider | Specialty | Location | Claims | Cost |
|---|---|---|---|---|---|
| 1 | George Plotkin | Neurology | Tyler, TX | 253 | $738K |
| 2 | Ramsey Falconer | Neurology | Alexandria, VA | 147 | $413K |
| 3 | Jyh-Haur Lu | Neurology | Flushing, NY | 185 | $399K |
| 4 | Stuart Isaacson | Neurology | Boca Raton, FL | 107 | $386K |
| 5 | Lin Zhang | Neurology | Sacramento, CA | 103 | $317K |
| 6 | Meredith Hatcher | Physician Assistant | Georgetown, TX | 87 | $311K |
| 7 | Joseph Rudolph | Neurology | Willoughby Hills, OH | 154 | $303K |
| 8 | Peter Michas-Martin | Neurology | Carmel, CA | 111 | $293K |
| 9 | Jessica Lawton | Physician Assistant | Mystic, CT | 105 | $291K |
| 10 | Jill Trumble | Neurology | Savannah, GA | 95 | $289K |
| 11 | Rajesh Pahwa | Neurology | Kansas City, KS | 75 | $240K |
| 12 | David Kreitzman | Neurology | Commack, NY | 100 | $220K |
| 13 | Pinky Agarwal | Neurology | Kirkland, WA | 96 | $216K |
| 14 | Raymond Capps | Neurology | Fort Walton Beach, FL | 79 | $205K |
| 15 | Brian Nagle | Neurology | Madison, WI | 63 | $204K |
Top prescribers ranked by total cost for this drug in 2023.
Related Drugs by Cost
| # | Drug | Total Cost | Claims |
|---|---|---|---|
| 439 | Posaconazole (Posaconazole) | $18.0M | 7,163 |
| 440 | Metronidazole (Metronidazole) | $18.0M | 405,967 |
| 441 | Rufinamide (Rufinamide) | $18.0M | 8,793 |
| 442 | Istradefylline (Nourianz) | $17.8M | 7,061 |
| 443 | Encorafenib (Braftovi) | $17.6M | 1,209 |
| 444 | Cladribine (Mavenclad) | $17.5M | 228 |
| 445 | Enalapril Maleate (Enalapril Maleate) | $17.5M | 673,317 |
Related Analysis
Data from CMS Medicare Part D Prescriber-Drug Public Use File, 2023. Methodology