Elexacaftor/Tezacaftor/Ivacaft
Brand name: Trikafta
Rank #69 of 500 drugs by total cost
Data: CMS Medicare Part D, 2023 (most current available) · Updated March 2026
$269.3M
Total Cost
9,821
Total Claims
$269.3M
Total Cost
148
Prescribers
$27K
Cost per Claim
850
Beneficiaries
10,041
30-Day Fills
$1.8M
Avg Cost/Provider
66
Avg Claims/Provider
Share of Medicare Part D Spending
0.10%
of total Medicare Part D spending
$269.3M of $275.65B
Top Prescribers by Cost
Top 10 prescribers of $269.3M total
🔎 Data Overview
At $27,423 per prescription, this is a high-cost medication. Expensive drugs drive Medicare spending growth and create access challenges for patients with coverage gaps.
Average cost of $1,819,766 per prescriber suggests this drug may be concentrated among specialists. High per-provider spending can sometimes indicate inappropriate prescribing or overly aggressive use.
Average cost of $316,853 per patient per year. Medications at this price point significantly impact patient out-of-pocket costs and Medicare spending.
Insights generated from CMS data analysis. Statistical patterns are not accusations — always consider clinical context.
Top Prescribers of Elexacaftor/Tezacaftor/Ivacaft
| # | Provider | Specialty | Location | Claims | Cost |
|---|---|---|---|---|---|
| 1 | Kapilkumar Patel | Pulmonary Disease | Tampa, FL | 496 | $13.7M |
| 2 | Joseph Pilewski | Pulmonary Disease | Pittsburgh, PA | 471 | $12.3M |
| 3 | William Hunt | Pulmonary Disease | Atlanta, GA | 285 | $7.9M |
| 4 | Jerry Nick | Pulmonary Disease | Denver, CO | 225 | $6.4M |
| 5 | Jonathan Zuckerman | Pulmonary Disease | South Portland, ME | 213 | $6.0M |
| 6 | George Solomon | Pulmonary Disease | Birmingham, AL | 220 | $5.9M |
| 7 | Maria Tupayachi Ortiz | Internal Medicine | Miami, FL | 218 | $5.9M |
| 8 | Virginia Satcher | Nurse Practitioner | Portland, OR | 209 | $5.7M |
| 9 | Holly Carveth | Pulmonary Disease | Salt Lake City, UT | 194 | $5.5M |
| 10 | Michael Anstead | Pulmonary Disease | Lexington, KY | 182 | $5.2M |
| 11 | Kimberly Mcbennett | Pediatric Medicine | Cleveland, OH | 187 | $5.0M |
| 12 | Larry Johnson | Pulmonary Disease | Little Rock, AR | 173 | $4.8M |
| 13 | Patricia Eshaghian | Pulmonary Disease | Los Angeles, CA | 145 | $3.9M |
| 14 | Isabel Neuringer | Critical Care (Intensivists) | Boston, MA | 138 | $3.9M |
| 15 | Emily Dimango | Pulmonary Disease | New York, NY | 144 | $3.8M |
Top prescribers ranked by total cost for this drug in 2023.
Related Drugs by Cost
| # | Drug | Total Cost | Claims |
|---|---|---|---|
| 66 | Budesonide/Glycopyr/Formoterol (Breztri Aerosphere) | $280.9M | 340,138 |
| 67 | Selexipag (Uptravi) | $279.1M | 12,320 |
| 68 | Liraglutide (Victoza 3-Pak) | $273.0M | 189,358 |
| 69 | Elexacaftor/Tezacaftor/Ivacaft (Trikafta) | $269.3M | 9,821 |
| 70 | Immune Globul G/Gly/Iga Avg 46 (Gamunex-C) | $266.5M | 27,501 |
| 71 | Rosuvastatin Calcium (Rosuvastatin Calcium) | $264.9M | 11,259,701 |
| 72 | Risankizumab-Rzaa (Skyrizi Pen) | $259.7M | 12,539 |
Related Analysis
Data from CMS Medicare Part D Prescriber-Drug Public Use File, 2023. Methodology