Zanubrutinib
Brand name: Brukinsa
Rank #74 of 500 drugs by total cost
Data: CMS Medicare Part D, 2023 (most current available) · Updated March 2026
$256.8M
Total Cost
19,239
Total Claims
$256.8M
Total Cost
810
Prescribers
$13K
Cost per Claim
417
Beneficiaries
19,329
30-Day Fills
$317K
Avg Cost/Provider
24
Avg Claims/Provider
Share of Medicare Part D Spending
0.09%
of total Medicare Part D spending
$256.8M of $275.65B
Top Prescribers by Cost
Top 10 prescribers of $256.8M total
🔎 Data Overview
At $13,350 per prescription, this is a high-cost medication. Expensive drugs drive Medicare spending growth and create access challenges for patients with coverage gaps.
Average cost of $317,087 per prescriber suggests this drug may be concentrated among specialists. High per-provider spending can sometimes indicate inappropriate prescribing or overly aggressive use.
Average cost of $615,924 per patient per year. Medications at this price point significantly impact patient out-of-pocket costs and Medicare spending.
Insights generated from CMS data analysis. Statistical patterns are not accusations — always consider clinical context.
Top Prescribers of Zanubrutinib
| # | Provider | Specialty | Location | Claims | Cost |
|---|---|---|---|---|---|
| 1 | Leslie Rudolph | Physician Assistant | New York, NY | 494 | $6.4M |
| 2 | Shayna Sarosiek | Hematology | Boston, MA | 233 | $3.1M |
| 3 | Melanie Bernstein | Physician Assistant | New York, NY | 170 | $2.5M |
| 4 | Camille Abboud | Medical Oncology | Saint Louis, MO | 152 | $2.2M |
| 5 | Clive Zent | Hematology | Rochester, NY | 119 | $1.6M |
| 6 | John Winters | Hematology-Oncology | Scarborough, ME | 99 | $1.5M |
| 7 | Thomas Kipps | Hematology-Oncology | La Jolla, CA | 99 | $1.5M |
| 8 | Sarah Miyata | Nurse Practitioner | Chicago, IL | 97 | $1.4M |
| 9 | Stefano Tarantolo | Medical Oncology | Omaha, NE | 115 | $1.4M |
| 10 | Lindsey Hendrickson | Nurse Practitioner | Charleston, SC | 98 | $1.4M |
| 11 | Parameswaren Venugopal | Hematology-Oncology | Chicago, IL | 87 | $1.3M |
| 12 | Brad Kahl | Medical Oncology | Saint Louis, MO | 94 | $1.3M |
| 13 | Suzanne Kirby | Hematology-Oncology | Cary, NC | 97 | $1.3M |
| 14 | Christina Bi | Pharmacist | Roseville, CA | 104 | $1.2M |
| 15 | Ian Flinn | Hematology-Oncology | Nashville, TN | 73 | $1.1M |
Top prescribers ranked by total cost for this drug in 2023.
Related Drugs by Cost
| # | Drug | Total Cost | Claims |
|---|---|---|---|
| 71 | Rosuvastatin Calcium (Rosuvastatin Calcium) | $264.9M | 11,259,701 |
| 72 | Risankizumab-Rzaa (Skyrizi Pen) | $259.7M | 12,539 |
| 73 | Venetoclax (Venclexta) | $259.6M | 28,191 |
| 74 | Zanubrutinib (Brukinsa) | $256.8M | 19,239 |
| 75 | Metoprolol Succinate (Metoprolol Succinate) | $256.3M | 12,847,535 |
| 76 | Dolutegravir Sodium (Tivicay) | $251.7M | 102,995 |
| 77 | Abemaciclib (Verzenio) | $242.2M | 16,125 |
Related Analysis
Data from CMS Medicare Part D Prescriber-Drug Public Use File, 2023. Methodology