Siponimod
Brand name: Mayzent
Rank #394 of 500 drugs by total cost
Data: CMS Medicare Part D, 2023 (most current available) · Updated March 2026
$23.5M
Total Cost
2,195
Total Claims
$23.5M
Total Cost
113
Prescribers
$11K
Cost per Claim
12
Beneficiaries
2,448
30-Day Fills
$208K
Avg Cost/Provider
19
Avg Claims/Provider
Share of Medicare Part D Spending
0.01%
of total Medicare Part D spending
$23.5M of $275.65B
Top Prescribers by Cost
Top 10 prescribers of $23.5M total
🔎 Data Overview
At $10,691 per prescription, this is a high-cost medication. Expensive drugs drive Medicare spending growth and create access challenges for patients with coverage gaps.
Average cost of $207,678 per prescriber suggests this drug may be concentrated among specialists. High per-provider spending can sometimes indicate inappropriate prescribing or overly aggressive use.
Average cost of $1,955,639 per patient per year. Medications at this price point significantly impact patient out-of-pocket costs and Medicare spending.
Insights generated from CMS data analysis. Statistical patterns are not accusations — always consider clinical context.
Top Prescribers of Siponimod
| # | Provider | Specialty | Location | Claims | Cost |
|---|---|---|---|---|---|
| 1 | Dana Beenstock | Nurse Practitioner | Freehold, NJ | 77 | $1.0M |
| 2 | Randall Trudell | Neurology | Knoxville, TN | 89 | $855K |
| 3 | Bruce Hughes | Neurology | Des Moines, IA | 55 | $663K |
| 4 | Caren Marks | Neurology | Freehold, NJ | 29 | $592K |
| 5 | Gabriel Pardo | Neurology | Oklahoma City, OK | 52 | $503K |
| 6 | Neil Lava | Neurology | Atlanta, GA | 48 | $482K |
| 7 | Edward Gettings | Neurology | Philadelphia, PA | 48 | $472K |
| 8 | Christopher Severson | Neurology | Boston, MA | 39 | $452K |
| 9 | Frank Benesh | Neurology | Birmingham, AL | 52 | $444K |
| 10 | Jong-Mi Lee | Nurse Practitioner | Stanford, CA | 43 | $407K |
| 11 | Douglas Goodin | Neurology | San Francisco, CA | 28 | $390K |
| 12 | Unsong Oh | Neurology | Richmond, VA | 34 | $383K |
| 13 | Aram Zabeti | Neurology | Cincinnati, OH | 41 | $368K |
| 14 | Katelyn Mccormack | Nurse Practitioner | Amherst, NY | 34 | $352K |
| 15 | Carrie Downey | Neurology | Bangor, ME | 29 | $332K |
Top prescribers ranked by total cost for this drug in 2023.
Related Drugs by Cost
| # | Drug | Total Cost | Claims |
|---|---|---|---|
| 391 | Empaglifloz/Linaglip/Metformin (Trijardy Xr) | $23.9M | 28,001 |
| 392 | Fluticasone Furoate (Arnuity Ellipta) | $23.7M | 74,825 |
| 393 | Lactulose (Lactulose) | $23.6M | 538,677 |
| 394 | Siponimod (Mayzent) | $23.5M | 2,195 |
| 395 | Droxidopa (Droxidopa) | $23.4M | 9,058 |
| 396 | Fenofibrate Nanocrystallized (Fenofibrate) | $23.2M | 602,181 |
| 397 | Ravulizumab-Cwvz (Ultomiris) | $23.1M | 428 |
Related Analysis
Data from CMS Medicare Part D Prescriber-Drug Public Use File, 2023. Methodology