Leuprolide Acetate
Brand name: Lupron Depot
Rank #279 of 500 drugs by total cost
Data: CMS Medicare Part D, 2023 (most current available) · Updated March 2026
$42.7M
Total Cost
9,949
Total Claims
$42.7M
Total Cost
303
Prescribers
$4,288
Cost per Claim
2,303
Beneficiaries
23,880
30-Day Fills
$141K
Avg Cost/Provider
33
Avg Claims/Provider
Share of Medicare Part D Spending
0.02%
of total Medicare Part D spending
$42.7M of $275.65B
Top Prescribers by Cost
Top 10 prescribers of $42.7M total
🔎 Data Overview
At $4,288 per prescription, this is a high-cost medication. Expensive drugs drive Medicare spending growth and create access challenges for patients with coverage gaps.
Average cost of $140,804 per prescriber suggests this drug may be concentrated among specialists. High per-provider spending can sometimes indicate inappropriate prescribing or overly aggressive use.
Average cost of $18,525 per patient per year. Medications at this price point significantly impact patient out-of-pocket costs and Medicare spending.
Insights generated from CMS data analysis. Statistical patterns are not accusations — always consider clinical context.
Top Prescribers of Leuprolide Acetate
| # | Provider | Specialty | Location | Claims | Cost |
|---|---|---|---|---|---|
| 1 | Ivan Colon | Urology | Brooklyn, NY | 305 | $1.9M |
| 2 | Dhanan Etwaru | Urology | Brooklyn, NY | 300 | $1.9M |
| 3 | Vitaly Raykhman | Urology | Brooklyn, NY | 110 | $1.3M |
| 4 | Eugenio Galindo | Hematology-Oncology | Mcallen, TX | 200 | $1.3M |
| 5 | Unni Mooppan | Urology | Brooklyn, NY | 177 | $1.1M |
| 6 | Dimitri Kessaris | Urology | Manhasset, NY | 159 | $1.0M |
| 7 | Ari Baron | Hematology-Oncology | San Francisco, CA | 152 | $969K |
| 8 | Avi Retter | Hematology-Oncology | Bronx, NY | 133 | $835K |
| 9 | Aftab Husain | Urology | Perth Amboy, NJ | 211 | $714K |
| 10 | Brent Yanke | Urology | Brooklyn, NY | 107 | $653K |
| 11 | Gopal Kunta | Medical Oncology | Clermont, FL | 89 | $561K |
| 12 | Daniel Lehman | Urology | Fishkill, NY | 83 | $523K |
| 13 | David Askin | Hematology-Oncology | Forest Hills, NY | 94 | $522K |
| 14 | Manish Dhawan | Hematology-Oncology | Minden, LA | 227 | $502K |
| 15 | Frederick Greenstein | Urology | Brooklyn, NY | 77 | $471K |
Top prescribers ranked by total cost for this drug in 2023.
Related Drugs by Cost
| # | Drug | Total Cost | Claims |
|---|---|---|---|
| 276 | Fluoxetine Hcl (Fluoxetine Hcl) | $43.9M | 2,891,768 |
| 277 | Patiromer Calcium Sorbitex (Veltassa) | $43.4M | 40,534 |
| 278 | Hydralazine Hcl (Hydralazine Hcl) | $43.2M | 2,256,779 |
| 279 | Leuprolide Acetate (Lupron Depot) | $42.7M | 9,949 |
| 280 | Efgartigimod Alfa-Fcab (Vyvgart) | $42.6M | 1,005 |
| 281 | Hydrochlorothiazide (Hydrochlorothiazide) | $42.4M | 7,879,021 |
| 282 | Tadalafil (Tadalafil) | $42.3M | 91,082 |
Related Analysis
Data from CMS Medicare Part D Prescriber-Drug Public Use File, 2023. Methodology