Leflunomide

Rank #463 of 500 drugs by total cost

Data: CMS Medicare Part D, 2023 (most current available) · Updated March 2026

$16.0M

Total Cost

205,765

Total Claims

$16.0M

Total Cost

3,273

Prescribers

$78

Cost per Claim

55,870

Beneficiaries

416,378

30-Day Fills

$4,875

Avg Cost/Provider

Avg Claims/Provider

Share of Medicare Part D Spending

0.01%

of total Medicare Part D spending

$16.0M of $275.65B

Top 10 prescribers of $16.0M total

#	Provider	Specialty	Location	Claims	Cost
1	Mansoor Ahmed	Rheumatology	Richmond, KY	921	$87K
2	Steven Cohen	Rheumatology	Tyler, TX	1,150	$83K
3	Noemi Varela-Rosario	Internal Medicine	Aguada, PR	1,223	$69K
4	William Rusche	Rheumatology	Bloomington, IN	393	$55K
5	Isam Diab	Rheumatology	Middleburg Hts, OH	474	$50K
6	Sheila Albuquerque	Rheumatology	Houston, TX	174	$44K
7	Lucia Hardi	Rheumatology	Lexington, KY	313	$44K
8	Thomas Conley	Rheumatology	Franklin, MA	389	$42K
9	Vinay Reddy	Rheumatology	Merrillville, IN	292	$41K
10	Maria Jones	Nurse Practitioner	Miamisburg, OH	375	$39K
11	Laura Howe	Rheumatology	Greeley, CO	500	$38K
12	Abdelnaser Elkhalili	Rheumatology	Webster, TX	416	$38K
13	Justina Tseng	Rheumatology	San Diego, CA	292	$37K
14	Daniel Jackson	Rheumatology	Akron, OH	216	$37K
15	Jorge Mundo	Rheumatology	Humacao, PR	452	$37K

Top prescribers ranked by total cost for this drug in 2023.

#	Drug	Total Cost	Claims
460	Letermovir (Prevymis)	$16.1M	2,144
461	Fluphenazine Hcl (Fluphenazine Hcl)	$16.0M	73,051
462	Nivolumab (Opdivo)	$16.0M	1,275
463	Leflunomide (Leflunomide)	$16.0M	205,765
464	Hydrocortisone (Hydrocortisone)	$15.9M	762,398
465	Digoxin (Digoxin)	$15.9M	548,410
466	Alpelisib (Piqray)	$15.7M	747

The 20 drugs that cost Medicare the most.

Why some providers resist cheaper generics.

How pharmacy benefit managers drive up drug prices.

Data from CMS Medicare Part D Prescriber-Drug Public Use File, 2023. Methodology