Lanadelumab-Flyo
Brand name: Takhzyro
Rank #191 of 500 drugs by total cost
Data: CMS Medicare Part D, 2023 (most current available) · Updated March 2026
$76.5M
Total Cost
1,670
Total Claims
$76.5M
Total Cost
82
Prescribers
$46K
Cost per Claim
25
Beneficiaries
1,688
30-Day Fills
$933K
Avg Cost/Provider
20
Avg Claims/Provider
Share of Medicare Part D Spending
0.03%
of total Medicare Part D spending
$76.5M of $275.65B
Top Prescribers by Cost
Top 10 prescribers of $76.5M total
🔎 Data Overview
At $45,834 per prescription, this is a high-cost medication. Expensive drugs drive Medicare spending growth and create access challenges for patients with coverage gaps.
Average cost of $933,458 per prescriber suggests this drug may be concentrated among specialists. High per-provider spending can sometimes indicate inappropriate prescribing or overly aggressive use.
Average cost of $3,061,742 per patient per year. Medications at this price point significantly impact patient out-of-pocket costs and Medicare spending.
Insights generated from CMS data analysis. Statistical patterns are not accusations — always consider clinical context.
Top Prescribers of Lanadelumab-Flyo
| # | Provider | Specialty | Location | Claims | Cost |
|---|---|---|---|---|---|
| 1 | Marc Riedl | Allergy/ Immunology | San Diego, CA | 127 | $6.2M |
| 2 | John Anderson | Pulmonary Disease | Homewood, AL | 87 | $4.3M |
| 3 | Michael Manning | Allergy/ Immunology | Scottsdale, AZ | 61 | $3.1M |
| 4 | Aneysa Sane | Allergy/ Immunology | Daleville, VA | 29 | $2.4M |
| 5 | Aleena Banerji | Allergy/ Immunology | Boston, MA | 55 | $2.4M |
| 6 | Jay Kashkin | Pediatric Medicine | Fair Lawn, NJ | 44 | $2.1M |
| 7 | Timothy Nickel | Internal Medicine | Tulsa, OK | 40 | $2.0M |
| 8 | Joshua Jacobs | Allergy/ Immunology | Walnut Creek, CA | 36 | $1.8M |
| 9 | Rafael Zaragoza Urdaz | Allergy/ Immunology | San Juan, PR | 45 | $1.5M |
| 10 | Carly Swint | Physician Assistant | Centennial, CO | 27 | $1.4M |
| 11 | Alan Katz | Allergy/ Immunology | North Dartmouth, MA | 28 | $1.4M |
| 12 | Corinna Bowser | Allergy/ Immunology | Narberth, PA | 27 | $1.4M |
| 13 | H Wedner | Allergy/ Immunology | Saint Louis, MO | 33 | $1.4M |
| 14 | Mark Davis-Lorton | Allergy/ Immunology | Tarrytown, NY | 37 | $1.3M |
| 15 | Paul Motta | Allergy/ Immunology | Dothan, AL | 25 | $1.3M |
Top prescribers ranked by total cost for this drug in 2023.
Related Drugs by Cost
| # | Drug | Total Cost | Claims |
|---|---|---|---|
| 188 | Celecoxib (Celecoxib) | $77.7M | 1,938,505 |
| 189 | Sod Phenylbutyrat/Taurursodiol (Relyvrio) | $77.0M | 6,152 |
| 190 | Pravastatin Sodium (Pravastatin Sodium) | $76.8M | 4,033,829 |
| 191 | Lanadelumab-Flyo (Takhzyro) | $76.5M | 1,670 |
| 192 | Diltiazem Hcl (Diltiazem 24hr Er (Cd)) | $75.9M | 1,846,124 |
| 193 | Carvedilol (Carvedilol) | $75.6M | 6,390,691 |
| 194 | Cannabidiol (Cbd) (Epidiolex) | $75.5M | 15,726 |
Related Analysis
Data from CMS Medicare Part D Prescriber-Drug Public Use File, 2023. Methodology