Opioid Pain Medications
11 drugs in this class, prescribed by 374,754 Medicare Part D providers.
Data: CMS Medicare Part D, 2023 (most current available) · Updated March 2026
$1.05B
Total Cost
23,323,774
Claims
11
Drugs
$45
Avg Cost/Claim
Key Insights
- Most expensive per prescription: Nucynta at $1,124/claim
- Most prescribed: Hydrocodone-Acetaminophen with 8,496,609 claims
- This class represents 0.4% of total Medicare Part D spending
All Opioid Pain Medications Drugs
| Drug | Cost | Claims |
|---|---|---|
| Oxycodone Hcl | $213.2M | 3,537,078 |
| Hydrocodone/Acetaminophen | $185.6M | 8,496,609 |
| Oxycodone Hcl/Acetaminophen | $136.4M | 3,487,099 |
| Buprenorphine Hcl/Naloxone Hcl | $135.8M | 696,008 |
| Oxycodone Myristate | $96.1M | 141,266 |
| Buprenorphine Hcl | $69.7M | 205,349 |
| Buprenorphine | $61.1M | 156,598 |
| Tramadol Hcl | $44.9M | 5,226,406 |
| Fentanyl | $36.2M | 324,419 |
| Tapentadol Hcl | $33.6M | 29,886 |
| Morphine Sulfate | $33.2M | 1,023,056 |